Profile of Tomas Lindahl, Paul Modrich, and Aziz Sancar, 2015 Nobel Laureates in Chemistry
نویسندگان
چکیده
منابع مشابه
Celebrating DNA’s Repair Crew
This year, the Nobel Prize in Chemistry has been awarded to Tomas Lindahl, Aziz Sancar, and Paul Modrich for their seminal studies of the mechanisms by which cells from bacteria to man repair DNA damage that is generated by normal cellular metabolism and stress from the environment. These studies beautifully illustrate the remarkable power of DNA repair to influence life from evolution through ...
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You can read the Nobel Prize Web site for the best description of the science behind the 2013 Nobel Prize in Chemistry. However, let me tell you what the beginnings of the science and its immediate impact were really like–a personal account from a close bystander and indirect collaborator in a neighboring field who grew up scientifically with two of the laureates, and knows well the third. The ...
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متن کاملThe current state of eukaryotic DNA base damage and repair
DNA damage is a natural hazard of life. The most common DNA lesions are base, sugar, and single-strand break damage resulting from oxidation, alkylation, deamination, and spontaneous hydrolysis. If left unrepaired, such lesions can become fixed in the genome as permanent mutations. Thus, evolution has led to the creation of several highly conserved, partially redundant pathways to repair or mit...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2015
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1521829112